Drug interactions
Entecavir + Foscarnet
Severity: Moderate
Entecavir and Foscarnet: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Foscarnet is nephrotoxic and entecavir is eliminated mainly by the kidney, so reduced renal function could raise entecavir levels. Entecavir is also secreted by tubular transport, though a direct competition effect with foscarnet is not well documented.
What this interaction means in plain words
Entecavir and Foscarnet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entecavir belongs to Anti Virals; Foscarnet belongs to Anti Virals.
Why it happens
Foscarnet-related renal impairment may reduce renal clearance of entecavir; competition for tubular secretion is possible but unproven.
What to do
Monitor serum creatinine during foscarnet therapy and adjust the entecavir dose to creatinine clearance. Watch for entecavir adverse effects such as lactic acidosis if renal function falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Other interactions of Entecavir
Frequently asked questions
Can I take Entecavir with Foscarnet?
MediHelp rates the interaction as moderate. Entecavir and Foscarnet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Foscarnet is nephrotoxic and entecavir is eliminated mainly by the kidney, so reduced renal function could raise entecavir levels. Entecavir is also secreted by tubular transport, though a direct competition effect with foscarnet is not well documented.
How serious is the interaction between Entecavir and Foscarnet?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine during foscarnet therapy and adjust the entecavir dose to creatinine clearance. Watch for entecavir adverse effects such as lactic acidosis if renal function falls.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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