Drug interactions
Entecavir + Glipizide-metformin
Severity: Moderate
Entecavir and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entecavir labeling warns of lactic acidosis, and metformin also carries this risk, so the combination may be additive in susceptible patients. A direct pharmacokinetic interaction is not established.
What this interaction means in plain words
Entecavir and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entecavir belongs to Anti Virals; Glipizide-metformin belongs to Endocrine.
Why it happens
Additive risk of lactic acidosis (nucleoside analogue mitochondrial toxicity and metformin-related lactate accumulation).
What to do
Monitor for symptoms of lactic acidosis and check renal and hepatic function, stopping metformin if it develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Entecavir
Frequently asked questions
Can I take Entecavir with Glipizide-metformin?
MediHelp rates the interaction as moderate. Entecavir and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entecavir labeling warns of lactic acidosis, and metformin also carries this risk, so the combination may be additive in susceptible patients. A direct pharmacokinetic interaction is not established.
How serious is the interaction between Entecavir and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for symptoms of lactic acidosis and check renal and hepatic function, stopping metformin if it develops.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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