Drug interactions
Entecavir + Glyburide-metformin
Severity: Moderate
Entecavir and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both entecavir and metformin have been associated with lactic acidosis, and entecavir is renally eliminated. Co-use may add to this risk, especially with renal impairment or liver disease.
What this interaction means in plain words
Entecavir and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entecavir belongs to Anti Virals; Glyburide-metformin belongs to Endocrine.
Why it happens
Additive risk of lactic acidosis; nucleoside analogues can impair mitochondrial function, and metformin inhibits mitochondrial respiration.
What to do
Monitor renal function and watch for symptoms of lactic acidosis such as malaise, nausea and rapid breathing. Stop treatment if lactic acidosis is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Entecavir and Glyburide-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glyburide-metformin
Other interactions of Entecavir
Frequently asked questions
Can I take Entecavir with Glyburide-metformin?
MediHelp rates the interaction as moderate. Entecavir and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both entecavir and metformin have been associated with lactic acidosis, and entecavir is renally eliminated. Co-use may add to this risk, especially with renal impairment or liver disease.
How serious is the interaction between Entecavir and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and watch for symptoms of lactic acidosis such as malaise, nausea and rapid breathing. Stop treatment if lactic acidosis is suspected.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
