Drug interactions
Entecavir + Hydrochlorothiazide-telmisartan
Severity: Minor
Entecavir and Hydrochlorothiazide-telmisartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entecavir is eliminated renally by filtration and tubular secretion, so drugs that reduce renal function could raise its levels. Hydrochlorothiazide and telmisartan have no established significant effect on entecavir, though volume depletion and renal impairment may matter.
What this interaction means in plain words
Entecavir and Hydrochlorothiazide-telmisartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entecavir belongs to Anti Virals; Hydrochlorothiazide-telmisartan belongs to Cardiovascular.
Why it happens
Possible reduced renal clearance with renal function decline or tubular competition; not clearly established for these drugs.
What to do
Monitor renal function, and adjust entecavir dose according to creatinine clearance if kidney function declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Entecavir
Frequently asked questions
Can I take Entecavir with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as minor. Entecavir and Hydrochlorothiazide-telmisartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Entecavir is eliminated renally by filtration and tubular secretion, so drugs that reduce renal function could raise its levels. Hydrochlorothiazide and telmisartan have no established significant effect on entecavir, though volume depletion and renal impairment may matter.
How serious is the interaction between Entecavir and Hydrochlorothiazide-telmisartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, and adjust entecavir dose according to creatinine clearance if kidney function declines.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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