Drug interactions
Entecavir + Hydrochlorothiazide-valsartan
Severity: Minor
Entecavir and Hydrochlorothiazide-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entecavir is eliminated by the kidneys through filtration and tubular secretion, so drugs that reduce renal function may raise its levels. Hydrochlorothiazide-induced volume depletion could have a similar effect, though clinically significant changes are uncommon.
What this interaction means in plain words
Entecavir and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entecavir belongs to Anti Virals; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Possible reduction in renal clearance of entecavir through volume depletion or transporter competition.
What to do
Monitor renal function and adjust entecavir dose to creatinine clearance if function declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Entecavir
Frequently asked questions
Can I take Entecavir with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as minor. Entecavir and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Entecavir is eliminated by the kidneys through filtration and tubular secretion, so drugs that reduce renal function may raise its levels. Hydrochlorothiazide-induced volume depletion could have a similar effect, though clinically significant changes are uncommon.
How serious is the interaction between Entecavir and Hydrochlorothiazide-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and adjust entecavir dose to creatinine clearance if function declines.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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