Drug interactions
Entecavir + Metformin-repaglinide
Severity: Moderate
Entecavir and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both entecavir and metformin have been associated with lactic acidosis, so using them together may increase that risk, especially with renal impairment or hepatic disease. Both drugs are renally eliminated, which adds to the concern.
What this interaction means in plain words
Entecavir and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entecavir belongs to Anti Virals; Metformin-repaglinide belongs to Endocrine.
Why it happens
Additive risk of lactic acidosis; both drugs are renally cleared and entecavir may impair mitochondrial function.
What to do
Monitor renal function and watch for symptoms of lactic acidosis such as malaise, myalgia, and rapid breathing. Avoid the combination in patients with significant renal or hepatic impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Entecavir
Frequently asked questions
Can I take Entecavir with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Entecavir and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both entecavir and metformin have been associated with lactic acidosis, so using them together may increase that risk, especially with renal impairment or hepatic disease. Both drugs are renally eliminated, which adds to the concern.
How serious is the interaction between Entecavir and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and watch for symptoms of lactic acidosis such as malaise, myalgia, and rapid breathing. Avoid the combination in patients with significant renal or hepatic impairment.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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