Drug interactions
Entecavir + Polymyxin b
Severity: Moderate
Entecavir and Polymyxin b: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parenteral polymyxin B is notably nephrotoxic. Kidney injury could reduce entecavir clearance and raise its levels.
What this interaction means in plain words
Entecavir and Polymyxin b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entecavir belongs to Anti Virals; Polymyxin b belongs to Anti Bacterial.
Why it happens
Polymyxin B nephrotoxicity decreases renal clearance of entecavir.
What to do
Monitor renal function closely and adjust the entecavir dose to creatinine clearance if it declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Entecavir
Other interactions of Polymyxin b
- Cidofovir + Polymyxin b Contraindicated
- Colistin + Polymyxin b Contraindicated
- Acyclovir + Polymyxin b Major
- Adefovir + Polymyxin b Major
- Amikacin + Polymyxin b Major
- Amphotericin b + Polymyxin b Major
Frequently asked questions
Can I take Entecavir with Polymyxin b?
MediHelp rates the interaction as moderate. Entecavir and Polymyxin b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parenteral polymyxin B is notably nephrotoxic. Kidney injury could reduce entecavir clearance and raise its levels.
How serious is the interaction between Entecavir and Polymyxin b?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function closely and adjust the entecavir dose to creatinine clearance if it declines.
What other medicines interact with Entecavir?
MediHelp also lists interactions of Entecavir with, for example, Alogliptin-metformin, Canagliflozin-metformin, Cidofovir. The full list is on the Entecavir page.
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