Drug interactions
Entecavir + Sacubitril-valsartan
Severity: Minor
Entecavir and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entecavir is eliminated by the kidneys through filtration and tubular secretion. Drugs that affect renal function could raise entecavir levels, but sacubitril/valsartan has no established direct effect on entecavir clearance.
What this interaction means in plain words
Entecavir and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entecavir belongs to Anti Virals; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Possible shared renal elimination or altered renal function; no direct transporter interaction is firmly established.
What to do
No empirical dose change is needed. Monitor renal function and adjust entecavir dose if creatinine clearance declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Entecavir
Frequently asked questions
Can I take Entecavir with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Entecavir and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Entecavir is eliminated by the kidneys through filtration and tubular secretion. Drugs that affect renal function could raise entecavir levels, but sacubitril/valsartan has no established direct effect on entecavir clearance.
How serious is the interaction between Entecavir and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor renal function and adjust entecavir dose if creatinine clearance declines.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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