Drug interactions
Entecavir + Streptomycin
Severity: Moderate
Entecavir and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are eliminated by the kidney, and entecavir undergoes some tubular secretion. Combined use may raise levels of either drug if renal function falls. Streptomycin nephrotoxicity could further reduce entecavir clearance.
What this interaction means in plain words
Entecavir and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entecavir belongs to Anti Virals; Streptomycin belongs to Anti Bacterial.
Why it happens
Competition for renal elimination and potential aminoglycoside-induced reduction in glomerular filtration.
What to do
Monitor serum creatinine during concurrent use and adjust entecavir dosing interval to creatinine clearance. Monitor streptomycin levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Streptomycin
Other interactions of Entecavir
Frequently asked questions
Can I take Entecavir with Streptomycin?
MediHelp rates the interaction as moderate. Entecavir and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are eliminated by the kidney, and entecavir undergoes some tubular secretion. Combined use may raise levels of either drug if renal function falls. Streptomycin nephrotoxicity could further reduce entecavir clearance.
How serious is the interaction between Entecavir and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine during concurrent use and adjust entecavir dosing interval to creatinine clearance. Monitor streptomycin levels.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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