Drug interactions
Entecavir + Tobramycin
Severity: Moderate
Entecavir and Tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tobramycin is nephrotoxic and entecavir is eliminated renally by filtration and tubular secretion. Reduced renal function from tobramycin may raise entecavir exposure.
What this interaction means in plain words
Entecavir and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entecavir belongs to Anti Virals; Tobramycin belongs to Anti Bacterial.
Why it happens
Aminoglycoside-induced renal impairment reduces entecavir clearance, with possible competition for renal elimination.
What to do
Monitor serum creatinine and tobramycin levels, and adjust entecavir dosing according to creatinine clearance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Other interactions of Entecavir
Frequently asked questions
Can I take Entecavir with Tobramycin?
MediHelp rates the interaction as moderate. Entecavir and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tobramycin is nephrotoxic and entecavir is eliminated renally by filtration and tubular secretion. Reduced renal function from tobramycin may raise entecavir exposure.
How serious is the interaction between Entecavir and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and tobramycin levels, and adjust entecavir dosing according to creatinine clearance.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
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