Drug interactions
Entecavir + Valganciclovir
Severity: Minor
Entecavir and Valganciclovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganciclovir and entecavir are both eliminated by glomerular filtration and active tubular secretion, so concentrations of either could rise when they are combined. Documented clinical effects are limited, but renal impairment increases the concern.
What this interaction means in plain words
Entecavir and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entecavir belongs to Anti Virals; Valganciclovir belongs to Anti Virals.
Why it happens
Possible competition for active renal tubular secretion.
What to do
Monitor renal function and adverse effects of both drugs, and dose each according to creatinine clearance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valganciclovir
Other interactions of Entecavir
Frequently asked questions
Can I take Entecavir with Valganciclovir?
MediHelp rates the interaction as minor. Entecavir and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ganciclovir and entecavir are both eliminated by glomerular filtration and active tubular secretion, so concentrations of either could rise when they are combined. Documented clinical effects are limited, but renal impairment increases the concern.
How serious is the interaction between Entecavir and Valganciclovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and adverse effects of both drugs, and dose each according to creatinine clearance.
What other medicines interact with Valganciclovir?
MediHelp also lists interactions of Valganciclovir with, for example, Didanosine, Ganciclovir, Liposomal doxorubicin. The full list is on the Valganciclovir page.
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