Drug interactions
Entrectinib + Goserelin
Severity: Major
Entrectinib and Goserelin: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval and goserelin may add a further effect via androgen deprivation. The combination may increase the likelihood of ventricular arrhythmia, particularly with other risk factors.
What this interaction means in plain words
Entrectinib and Goserelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Entrectinib belongs to Oncology; Goserelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain a baseline ECG and electrolytes and monitor periodically. Correct electrolyte abnormalities, and follow entrectinib labeling for dose reduction or interruption if QTc rises significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Goserelin
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Goserelin?
MediHelp rates the interaction as major. Entrectinib and Goserelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Entrectinib can prolong the QT interval and goserelin may add a further effect via androgen deprivation. The combination may increase the likelihood of ventricular arrhythmia, particularly with other risk factors.
How serious is the interaction between Entrectinib and Goserelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and electrolytes and monitor periodically. Correct electrolyte abnormalities, and follow entrectinib labeling for dose reduction or interruption if QTc rises significantly.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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