Drug interactions
Entrectinib + Hydroxychloroquine
Severity: Major
Entrectinib and Hydroxychloroquine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval, and hydroxychloroquine has the same liability. Together they increase the risk of torsades de pointes and other ventricular arrhythmias.
What this interaction means in plain words
Entrectinib and Hydroxychloroquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Entrectinib belongs to Oncology; Hydroxychloroquine belongs to Musculoskeletal.
Why it happens
Additive prolongation of cardiac repolarization causes additive QT prolongation.
What to do
Avoid the combination if an alternative exists. If it is unavoidable, monitor the ECG and electrolytes and follow the entrectinib labeling for dose reduction or interruption when the QTc is prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Hydroxychloroquine?
MediHelp rates the interaction as major. Entrectinib and Hydroxychloroquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Entrectinib can prolong the QT interval, and hydroxychloroquine has the same liability. Together they increase the risk of torsades de pointes and other ventricular arrhythmias.
How serious is the interaction between Entrectinib and Hydroxychloroquine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative exists. If it is unavoidable, monitor the ECG and electrolytes and follow the entrectinib labeling for dose reduction or interruption when the QTc is prolonged.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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