Drug interactions
Entrectinib + Indacaterol
Severity: Moderate
Entrectinib and Indacaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval and indacaterol may add to this through beta-adrenergic effects and hypokalemia. Together they may increase the risk of ventricular arrhythmias.
What this interaction means in plain words
Entrectinib and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entrectinib belongs to Oncology; Indacaterol belongs to Respiratory.
Why it happens
Additive QT prolongation.
What to do
Obtain a baseline ECG and monitor QTc and electrolytes during coadministration. Correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Indacaterol?
MediHelp rates the interaction as moderate. Entrectinib and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entrectinib can prolong the QT interval and indacaterol may add to this through beta-adrenergic effects and hypokalemia. Together they may increase the risk of ventricular arrhythmias.
How serious is the interaction between Entrectinib and Indacaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes during coadministration. Correct hypokalemia and hypomagnesemia.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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