Drug interactions
Entrectinib + Mirtazapine
Severity: Moderate
Entrectinib and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval, and mirtazapine may add to this risk. Combined use raises the potential for ventricular arrhythmia, especially with electrolyte disturbance.
What this interaction means in plain words
Entrectinib and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entrectinib belongs to Oncology; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization (QT interval).
What to do
Obtain ECG and electrolytes at baseline and during therapy. Reduce or stop entrectinib or reconsider mirtazapine if QT prolongation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Mirtazapine?
MediHelp rates the interaction as moderate. Entrectinib and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entrectinib can prolong the QT interval, and mirtazapine may add to this risk. Combined use raises the potential for ventricular arrhythmia, especially with electrolyte disturbance.
How serious is the interaction between Entrectinib and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECG and electrolytes at baseline and during therapy. Reduce or stop entrectinib or reconsider mirtazapine if QT prolongation develops.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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