Drug interactions
Entrectinib + Sotalol
Severity: Major
Entrectinib and Sotalol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval, and sotalol is a class III antiarrhythmic with well-known torsadogenic potential. Combined use increases the chance of serious ventricular arrhythmia.
What this interaction means in plain words
Entrectinib and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Entrectinib belongs to Oncology; Sotalol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic prolongation of cardiac repolarization.
What to do
Avoid concurrent use if possible; otherwise monitor ECG and electrolytes regularly and correct hypokalemia or hypomagnesemia. Consider an alternative antiarrhythmic or oncology therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Sotalol?
MediHelp rates the interaction as major. Entrectinib and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Entrectinib can prolong the QT interval, and sotalol is a class III antiarrhythmic with well-known torsadogenic potential. Combined use increases the chance of serious ventricular arrhythmia.
How serious is the interaction between Entrectinib and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if possible; otherwise monitor ECG and electrolytes regularly and correct hypokalemia or hypomagnesemia. Consider an alternative antiarrhythmic or oncology therapy.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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