Drug interactions
Entrectinib + Trazodone
Severity: Moderate
Entrectinib and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval and trazodone adds to this effect, increasing the risk of ventricular arrhythmia. Patients with cardiac disease or electrolyte disturbances are at the highest risk.
What this interaction means in plain words
Entrectinib and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entrectinib belongs to Oncology; Trazodone belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Check an ECG and electrolytes at baseline and during therapy. Consider an alternative antidepressant or dose reduction if the QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Trazodone?
MediHelp rates the interaction as moderate. Entrectinib and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entrectinib can prolong the QT interval and trazodone adds to this effect, increasing the risk of ventricular arrhythmia. Patients with cardiac disease or electrolyte disturbances are at the highest risk.
How serious is the interaction between Entrectinib and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG and electrolytes at baseline and during therapy. Consider an alternative antidepressant or dose reduction if the QTc becomes prolonged.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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