Drug interactions
Enzalutamide + Erythromycin base
Severity: Moderate
Enzalutamide and Erythromycin base: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin is metabolized by CYP3A4, and enzalutamide strongly induces this enzyme. Erythromycin concentrations may drop and cause antibacterial failure. Erythromycin also inhibits CYP3A4 and may raise enzalutamide exposure slightly.
What this interaction means in plain words
Enzalutamide and Erythromycin base can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enzalutamide induces CYP3A4, increasing erythromycin metabolism.
What to do
Monitor for clinical response to the antibiotic, or choose a non-CYP3A4-dependent agent such as azithromycin or another class suited to the infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Erythromycin base?
MediHelp rates the interaction as moderate. Enzalutamide and Erythromycin base can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin is metabolized by CYP3A4, and enzalutamide strongly induces this enzyme. Erythromycin concentrations may drop and cause antibacterial failure. Erythromycin also inhibits CYP3A4 and may raise enzalutamide exposure slightly.
How serious is the interaction between Enzalutamide and Erythromycin base?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for clinical response to the antibiotic, or choose a non-CYP3A4-dependent agent such as azithromycin or another class suited to the infection.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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