Drug interactions
Enzalutamide + Escitalopram
Severity: Moderate
Enzalutamide and Escitalopram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 and moderate CYP2C19 inducer and may lower escitalopram concentrations, which could reduce antidepressant effect. The effect is a loss of efficacy rather than toxicity.
What this interaction means in plain words
Enzalutamide and Escitalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Escitalopram belongs to Central Nervous System.
Why it happens
Enzalutamide induces CYP3A4 and CYP2C19, increasing the metabolism of escitalopram.
What to do
Monitor for reduced antidepressant response and titrate escitalopram to effect within the maximum dose. Reassess the dose after enzalutamide is stopped, as induction wanes over weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Escitalopram?
MediHelp rates the interaction as moderate. Enzalutamide and Escitalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 and moderate CYP2C19 inducer and may lower escitalopram concentrations, which could reduce antidepressant effect. The effect is a loss of efficacy rather than toxicity.
How serious is the interaction between Enzalutamide and Escitalopram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antidepressant response and titrate escitalopram to effect within the maximum dose. Reassess the dose after enzalutamide is stopped, as induction wanes over weeks.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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