Drug interactions
Enzalutamide + Estropipate
Severity: Moderate
Enzalutamide and Estropipate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide induces CYP3A4, which contributes to estrogen metabolism, so estrone exposure from estropipate may fall. Menopausal symptom control may be reduced and breakthrough bleeding may occur.
What this interaction means in plain words
Enzalutamide and Estropipate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enzalutamide induces CYP3A4, accelerating estrogen clearance.
What to do
Monitor symptom control and bleeding patterns and adjust the estrogen dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Estropipate?
MediHelp rates the interaction as moderate. Enzalutamide and Estropipate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide induces CYP3A4, which contributes to estrogen metabolism, so estrone exposure from estropipate may fall. Menopausal symptom control may be reduced and breakthrough bleeding may occur.
How serious is the interaction between Enzalutamide and Estropipate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and bleeding patterns and adjust the estrogen dose if needed.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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