Drug interactions
Enzalutamide + Etoposide
Severity: Moderate
Enzalutamide and Etoposide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etoposide is partly metabolized by CYP3A4, so enzalutamide may lower its exposure. The clinical effect is uncertain but could reduce antitumor activity.
What this interaction means in plain words
Enzalutamide and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Etoposide belongs to Oncology.
Why it happens
Enzalutamide induces CYP3A4, which may increase etoposide clearance.
What to do
Monitor treatment response and hematologic toxicity. No empirical dose change is recommended.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Frequently asked questions
Can I take Enzalutamide with Etoposide?
MediHelp rates the interaction as moderate. Enzalutamide and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etoposide is partly metabolized by CYP3A4, so enzalutamide may lower its exposure. The clinical effect is uncertain but could reduce antitumor activity.
How serious is the interaction between Enzalutamide and Etoposide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor treatment response and hematologic toxicity. No empirical dose change is recommended.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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