Drug interactions
Enzalutamide + Exemestane
Severity: Moderate
Enzalutamide and Exemestane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Exemestane is metabolized by CYP3A4, and strong inducers lower its levels. Labeling recommends a higher exemestane dose when given with strong inducers.
What this interaction means in plain words
Enzalutamide and Exemestane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Exemestane belongs to Oncology.
Why it happens
Enzalutamide induces CYP3A4, increasing exemestane metabolism.
What to do
Consider increasing exemestane from 25 mg to 50 mg daily during concurrent use, and monitor response. Return to the usual dose after enzalutamide is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Exemestane
Frequently asked questions
Can I take Enzalutamide with Exemestane?
MediHelp rates the interaction as moderate. Enzalutamide and Exemestane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Exemestane is metabolized by CYP3A4, and strong inducers lower its levels. Labeling recommends a higher exemestane dose when given with strong inducers.
How serious is the interaction between Enzalutamide and Exemestane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider increasing exemestane from 25 mg to 50 mg daily during concurrent use, and monitor response. Return to the usual dose after enzalutamide is stopped.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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