Drug interactions
Enzalutamide + Fexinidazole
Severity: Major
Enzalutamide and Fexinidazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP inducers such as enzalutamide may alter fexinidazole metabolism, raising active metabolite exposure including the sulfone linked to QT prolongation. Fexinidazole may in turn inhibit CYP3A4 and affect enzalutamide levels. The combination has uncertain effects on efficacy and cardiac safety.
What this interaction means in plain words
Enzalutamide and Fexinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Enzalutamide induces CYP enzymes that change fexinidazole metabolite formation, and fexinidazole inhibits CYP3A4.
What to do
Avoid the combination. If unavoidable, perform ECG monitoring and correct electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Fexinidazole?
MediHelp rates the interaction as major. Enzalutamide and Fexinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP inducers such as enzalutamide may alter fexinidazole metabolism, raising active metabolite exposure including the sulfone linked to QT prolongation. Fexinidazole may in turn inhibit CYP3A4 and affect enzalutamide levels. The combination has uncertain effects on efficacy and cardiac safety.
How serious is the interaction between Enzalutamide and Fexinidazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If unavoidable, perform ECG monitoring and correct electrolytes.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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