Drug interactions
Enzalutamide + Flotufolastat f
Severity: Moderate
Enzalutamide and Flotufolastat f: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen receptor-targeted therapy can alter PSMA expression and thus tracer uptake in prostate cancer. This may change the appearance of flotufolastat F 18 PET scans, and the effect on diagnostic performance has not been established.
What this interaction means in plain words
Enzalutamide and Flotufolastat f can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Androgen pathway inhibition modulates PSMA expression, which may alter radiotracer uptake; not a metabolic interaction.
What to do
Make the imaging team aware of current enzalutamide therapy and interpret the PET findings in that context. Consider timing of imaging relative to treatment decisions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Flotufolastat f?
MediHelp rates the interaction as moderate. Enzalutamide and Flotufolastat f can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen receptor-targeted therapy can alter PSMA expression and thus tracer uptake in prostate cancer. This may change the appearance of flotufolastat F 18 PET scans, and the effect on diagnostic performance has not been established.
How serious is the interaction between Enzalutamide and Flotufolastat f?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Make the imaging team aware of current enzalutamide therapy and interpret the PET findings in that context. Consider timing of imaging relative to treatment decisions.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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