Drug interactions
Enzalutamide + Flurazepam
Severity: Minor
Enzalutamide and Flurazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurazepam's active metabolites are partly cleared via CYP3A4, so enzalutamide may reduce their exposure. The hypnotic effect may be weaker.
What this interaction means in plain words
Enzalutamide and Flurazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Enzalutamide induces CYP3A4, increasing benzodiazepine metabolite clearance.
What to do
Monitor for reduced sleep effect and adjust the dose or choose a non-CYP3A4 hypnotic if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Flurazepam?
MediHelp rates the interaction as minor. Enzalutamide and Flurazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Flurazepam's active metabolites are partly cleared via CYP3A4, so enzalutamide may reduce their exposure. The hypnotic effect may be weaker.
How serious is the interaction between Enzalutamide and Flurazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced sleep effect and adjust the dose or choose a non-CYP3A4 hypnotic if needed.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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