Drug interactions
Enzalutamide + Isradipine
Severity: Moderate
Enzalutamide and Isradipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide may considerably reduce isradipine concentrations, leading to loss of blood pressure control. Isradipine is extensively metabolized by CYP3A4 and has high first-pass clearance.
What this interaction means in plain words
Enzalutamide and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enzalutamide induces intestinal and hepatic CYP3A4, increasing isradipine clearance.
What to do
Monitor blood pressure and heart rate when starting or stopping enzalutamide, and titrate isradipine upward as needed. Consider an alternative antihypertensive not dependent on CYP3A4 if control is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Isradipine?
MediHelp rates the interaction as moderate. Enzalutamide and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide may considerably reduce isradipine concentrations, leading to loss of blood pressure control. Isradipine is extensively metabolized by CYP3A4 and has high first-pass clearance.
How serious is the interaction between Enzalutamide and Isradipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or stopping enzalutamide, and titrate isradipine upward as needed. Consider an alternative antihypertensive not dependent on CYP3A4 if control is inadequate.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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