Drug interactions
Enzalutamide + Levonorgestrel intrauterine
Severity: Minor
Enzalutamide and Levonorgestrel intrauterine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide may increase levonorgestrel metabolism, but the intrauterine system acts mainly locally with low systemic exposure. Contraceptive and endometrial protection are likely preserved.
What this interaction means in plain words
Enzalutamide and Levonorgestrel intrauterine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 induction could lower systemic levonorgestrel, with limited effect on local uterine concentrations.
What to do
No change is generally required; advise that effective contraception is still needed during enzalutamide therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Levonorgestrel intrauterine?
MediHelp rates the interaction as minor. Enzalutamide and Levonorgestrel intrauterine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Enzalutamide may increase levonorgestrel metabolism, but the intrauterine system acts mainly locally with low systemic exposure. Contraceptive and endometrial protection are likely preserved.
How serious is the interaction between Enzalutamide and Levonorgestrel intrauterine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is generally required; advise that effective contraception is still needed during enzalutamide therapy.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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