Drug interactions
Enzalutamide + Marijuana
Severity: Minor
Enzalutamide and Marijuana: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide may lower exposure to THC and CBD, which are partly metabolized by CYP3A4, though clinical data are lacking. Effects are likely a reduced cannabinoid effect.
What this interaction means in plain words
Enzalutamide and Marijuana have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Enzalutamide induces CYP3A4, possibly increasing cannabinoid metabolism.
What to do
Be aware the cannabinoid effect may be diminished; titrate to response if cannabis is used therapeutically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Marijuana?
MediHelp rates the interaction as minor. Enzalutamide and Marijuana have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Enzalutamide may lower exposure to THC and CBD, which are partly metabolized by CYP3A4, though clinical data are lacking. Effects are likely a reduced cannabinoid effect.
How serious is the interaction between Enzalutamide and Marijuana?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware the cannabinoid effect may be diminished; titrate to response if cannabis is used therapeutically.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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