Drug interactions
Enzalutamide + Mestranol
Severity: Major
Enzalutamide and Mestranol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide may reduce estrogen exposure from mestranol, which is converted to ethinylestradiol, and can reduce contraceptive effectiveness. Breakthrough bleeding or contraceptive failure may occur.
What this interaction means in plain words
Enzalutamide and Mestranol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Enzalutamide induces CYP3A4 and increases clearance of ethinylestradiol derived from mestranol.
What to do
Use an additional or alternative non-hormonal contraceptive method during and for a period after enzalutamide. Monitor for breakthrough bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Mestranol?
MediHelp rates the interaction as major. Enzalutamide and Mestranol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide may reduce estrogen exposure from mestranol, which is converted to ethinylestradiol, and can reduce contraceptive effectiveness. Breakthrough bleeding or contraceptive failure may occur.
How serious is the interaction between Enzalutamide and Mestranol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an additional or alternative non-hormonal contraceptive method during and for a period after enzalutamide. Monitor for breakthrough bleeding.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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