Drug interactions
Enzalutamide + Nirogacestat
Severity: Major
Enzalutamide and Nirogacestat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nirogacestat is metabolized by CYP3A4, so strong induction by enzalutamide is expected to reduce its exposure. Lower levels may lead to loss of efficacy in desmoid tumor treatment.
What this interaction means in plain words
Enzalutamide and Nirogacestat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Nirogacestat belongs to Oncology.
Why it happens
Enzalutamide induces CYP3A4, increasing nirogacestat clearance.
What to do
Avoid concurrent use of nirogacestat with strong CYP3A inducers such as enzalutamide. Consider an alternative to enzalutamide or an alternative therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Nirogacestat
Frequently asked questions
Can I take Enzalutamide with Nirogacestat?
MediHelp rates the interaction as major. Enzalutamide and Nirogacestat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nirogacestat is metabolized by CYP3A4, so strong induction by enzalutamide is expected to reduce its exposure. Lower levels may lead to loss of efficacy in desmoid tumor treatment.
How serious is the interaction between Enzalutamide and Nirogacestat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of nirogacestat with strong CYP3A inducers such as enzalutamide. Consider an alternative to enzalutamide or an alternative therapy.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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