Drug interactions
Enzalutamide + Norethindrone transdermal
Severity: Major
Enzalutamide and Norethindrone transdermal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide may reduce circulating norethindrone from a transdermal system, though the effect is less certain than with oral dosing. Contraceptive efficacy may be reduced and bleeding changes may occur.
What this interaction means in plain words
Enzalutamide and Norethindrone transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Enzalutamide induces CYP3A4, increasing metabolic clearance of norethindrone.
What to do
Advise an effective non-hormonal or barrier contraceptive method during therapy and for several weeks after enzalutamide is stopped. Do not rely on the patch alone.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Norethindrone transdermal?
MediHelp rates the interaction as major. Enzalutamide and Norethindrone transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide may reduce circulating norethindrone from a transdermal system, though the effect is less certain than with oral dosing. Contraceptive efficacy may be reduced and bleeding changes may occur.
How serious is the interaction between Enzalutamide and Norethindrone transdermal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an effective non-hormonal or barrier contraceptive method during therapy and for several weeks after enzalutamide is stopped. Do not rely on the patch alone.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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