Drug interactions
Enzalutamide + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Contraindicated
Enzalutamide and Ombitasvir / paritaprevir / ritonavir and dasabuvir: contraindicated interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A inducers lower paritaprevir and ritonavir concentrations, reducing HCV regimen efficacy; labeling contraindicates the combination. Ritonavir may increase enzalutamide levels.
What this interaction means in plain words
Enzalutamide and Ombitasvir / paritaprevir / ritonavir and dasabuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Enzalutamide induces CYP3A4, lowering paritaprevir and ritonavir; ritonavir inhibits CYP3A4 and may raise enzalutamide.
What to do
Do not coadminister; choose another HCV regimen or defer treatment. Monitor virologic response if exposure occurred.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as contraindicated. Enzalutamide and Ombitasvir / paritaprevir / ritonavir and dasabuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Strong CYP3A inducers lower paritaprevir and ritonavir concentrations, reducing HCV regimen efficacy; labeling contraindicates the combination. Ritonavir may increase enzalutamide levels.
How serious is the interaction between Enzalutamide and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; choose another HCV regimen or defer treatment. Monitor virologic response if exposure occurred.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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