Drug interactions
Enzalutamide + Ponatinib
Severity: Major
Enzalutamide and Ponatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib is a CYP3A4 substrate, and enzalutamide can reduce exposure, risking inadequate leukemia control.
What this interaction means in plain words
Enzalutamide and Ponatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Ponatinib belongs to Oncology.
Why it happens
Enzalutamide induces CYP3A4, increasing ponatinib metabolism.
What to do
Avoid unless benefit outweighs risk; monitor hematologic and molecular response closely. Consider an alternative to enzalutamide.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Ponatinib
Frequently asked questions
Can I take Enzalutamide with Ponatinib?
MediHelp rates the interaction as major. Enzalutamide and Ponatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ponatinib is a CYP3A4 substrate, and enzalutamide can reduce exposure, risking inadequate leukemia control.
How serious is the interaction between Enzalutamide and Ponatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless benefit outweighs risk; monitor hematologic and molecular response closely. Consider an alternative to enzalutamide.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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