Drug interactions
Enzalutamide + Progesterone intravaginal
Severity: Moderate
Enzalutamide and Progesterone intravaginal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide may reduce systemic progesterone exposure, though vaginal delivery partly bypasses first-pass metabolism. Endometrial protection or luteal support may be reduced.
What this interaction means in plain words
Enzalutamide and Progesterone intravaginal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enzalutamide induces CYP3A4, increasing progesterone metabolism.
What to do
Monitor for breakthrough bleeding or reduced efficacy and adjust therapy accordingly. Note enzalutamide is not indicated in women of childbearing potential.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Progesterone intravaginal?
MediHelp rates the interaction as moderate. Enzalutamide and Progesterone intravaginal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide may reduce systemic progesterone exposure, though vaginal delivery partly bypasses first-pass metabolism. Endometrial protection or luteal support may be reduced.
How serious is the interaction between Enzalutamide and Progesterone intravaginal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough bleeding or reduced efficacy and adjust therapy accordingly. Note enzalutamide is not indicated in women of childbearing potential.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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