Drug interactions
Enzalutamide + Progesterone natural
Severity: Moderate
Enzalutamide and Progesterone natural: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Natural progesterone is cleared by CYP3A4, and enzalutamide may lower exposure, reducing its therapeutic effect.
What this interaction means in plain words
Enzalutamide and Progesterone natural can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enzalutamide induces CYP3A4, accelerating progesterone metabolism.
What to do
Monitor for loss of efficacy such as breakthrough bleeding and adjust the regimen or choose an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Progesterone natural?
MediHelp rates the interaction as moderate. Enzalutamide and Progesterone natural can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Natural progesterone is cleared by CYP3A4, and enzalutamide may lower exposure, reducing its therapeutic effect.
How serious is the interaction between Enzalutamide and Progesterone natural?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of efficacy such as breakthrough bleeding and adjust the regimen or choose an alternative.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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