Drug interactions
Enzalutamide + Romidepsin
Severity: Moderate
Enzalutamide and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin is metabolized mainly by CYP3A4. Strong inducers such as enzalutamide may lower its concentrations and reduce efficacy.
What this interaction means in plain words
Enzalutamide and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by enzalutamide increases romidepsin metabolism.
What to do
Avoid prolonged use of strong CYP3A inducers with romidepsin when alternatives exist. Monitor lymphoma response if combined.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Romidepsin?
MediHelp rates the interaction as moderate. Enzalutamide and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Romidepsin is metabolized mainly by CYP3A4. Strong inducers such as enzalutamide may lower its concentrations and reduce efficacy.
How serious is the interaction between Enzalutamide and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged use of strong CYP3A inducers with romidepsin when alternatives exist. Monitor lymphoma response if combined.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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