Drug interactions
Enzalutamide + Selumetinib
Severity: Major
Enzalutamide and Selumetinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selumetinib is metabolized by CYP3A4, so strong inducers may lower exposure. Enzalutamide may reduce selumetinib efficacy.
What this interaction means in plain words
Enzalutamide and Selumetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Selumetinib belongs to Oncology.
Why it happens
Enzalutamide induces CYP3A4, increasing selumetinib metabolism.
What to do
Avoid strong and moderate CYP3A inducers with selumetinib. Select an alternative agent and monitor clinical response if unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Selumetinib
Frequently asked questions
Can I take Enzalutamide with Selumetinib?
MediHelp rates the interaction as major. Enzalutamide and Selumetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Selumetinib is metabolized by CYP3A4, so strong inducers may lower exposure. Enzalutamide may reduce selumetinib efficacy.
How serious is the interaction between Enzalutamide and Selumetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong and moderate CYP3A inducers with selumetinib. Select an alternative agent and monitor clinical response if unavoidable.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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