Drug interactions
Enzalutamide + Sofosbuvir / velpatasvir
Severity: Major
Enzalutamide and Sofosbuvir / velpatasvir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide may substantially lower velpatasvir and sofosbuvir exposure through enzyme and P-gp induction. This can lead to hepatitis C treatment failure.
What this interaction means in plain words
Enzalutamide and Sofosbuvir / velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Induction of CYP3A4, CYP2B6, CYP2C8 and P-glycoprotein by enzalutamide increases clearance of velpatasvir and sofosbuvir.
What to do
Do not coadminister; labeling advises against use with strong inducers. Defer HCV therapy or choose an alternative regimen.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as major. Enzalutamide and Sofosbuvir / velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide may substantially lower velpatasvir and sofosbuvir exposure through enzyme and P-gp induction. This can lead to hepatitis C treatment failure.
How serious is the interaction between Enzalutamide and Sofosbuvir / velpatasvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; labeling advises against use with strong inducers. Defer HCV therapy or choose an alternative regimen.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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