Drug interactions
Enzalutamide + Sufentanil sl
Severity: Major
Enzalutamide and Sufentanil sl: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide may lower sufentanil concentrations through CYP3A4 induction, causing reduced analgesia or withdrawal in dependent patients. Stopping enzalutamide may raise sufentanil levels and the risk of respiratory depression.
What this interaction means in plain words
Enzalutamide and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Enzalutamide induces CYP3A4, accelerating sufentanil metabolism.
What to do
Monitor pain control and withdrawal symptoms and adjust dose as needed. After stopping enzalutamide, monitor for sedation and respiratory depression and reduce the dose if necessary.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Sufentanil sl?
MediHelp rates the interaction as major. Enzalutamide and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide may lower sufentanil concentrations through CYP3A4 induction, causing reduced analgesia or withdrawal in dependent patients. Stopping enzalutamide may raise sufentanil levels and the risk of respiratory depression.
How serious is the interaction between Enzalutamide and Sufentanil sl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and withdrawal symptoms and adjust dose as needed. After stopping enzalutamide, monitor for sedation and respiratory depression and reduce the dose if necessary.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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