Drug interactions
Enzalutamide + Teniposide
Severity: Moderate
Enzalutamide and Teniposide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teniposide is metabolized by CYP3A4, and enzalutamide may lower its exposure, potentially reducing efficacy. Enzyme-inducing drugs have been shown to increase teniposide clearance.
What this interaction means in plain words
Enzalutamide and Teniposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enzalutamide induces CYP3A4, increasing teniposide clearance.
What to do
Monitor response and toxicity, and consider dose adjustment or an alternative regimen if efficacy is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Teniposide?
MediHelp rates the interaction as moderate. Enzalutamide and Teniposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teniposide is metabolized by CYP3A4, and enzalutamide may lower its exposure, potentially reducing efficacy. Enzyme-inducing drugs have been shown to increase teniposide clearance.
How serious is the interaction between Enzalutamide and Teniposide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor response and toxicity, and consider dose adjustment or an alternative regimen if efficacy is a concern.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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