Drug interactions
Enzalutamide + Tiagabine
Severity: Moderate
Enzalutamide and Tiagabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and tiagabine is cleared mainly by CYP3A4. Tiagabine concentrations may fall, which could reduce seizure control in patients who depend on it.
What this interaction means in plain words
Enzalutamide and Tiagabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enzalutamide induces CYP3A4, increasing the hepatic metabolism of tiagabine.
What to do
Monitor seizure frequency and tiagabine response when enzalutamide is started, and raise the tiagabine dose if needed. Reassess the dose if enzalutamide is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Tiagabine?
MediHelp rates the interaction as moderate. Enzalutamide and Tiagabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and tiagabine is cleared mainly by CYP3A4. Tiagabine concentrations may fall, which could reduce seizure control in patients who depend on it.
How serious is the interaction between Enzalutamide and Tiagabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency and tiagabine response when enzalutamide is started, and raise the tiagabine dose if needed. Reassess the dose if enzalutamide is stopped.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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