Drug interactions
Enzalutamide + Triazolam
Severity: Moderate
Enzalutamide and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triazolam is a sensitive CYP3A4 substrate, and enzalutamide is a strong CYP3A4 inducer. Exposure to triazolam can fall substantially, leading to loss of hypnotic effect or insomnia.
What this interaction means in plain words
Enzalutamide and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enzalutamide induces CYP3A4, accelerating the first-pass and hepatic metabolism of triazolam.
What to do
Monitor for reduced sedative effect and consider a different hypnotic that is not CYP3A4 dependent, such as temazepam. Avoid escalating triazolam doses without review.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Triazolam?
MediHelp rates the interaction as moderate. Enzalutamide and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triazolam is a sensitive CYP3A4 substrate, and enzalutamide is a strong CYP3A4 inducer. Exposure to triazolam can fall substantially, leading to loss of hypnotic effect or insomnia.
How serious is the interaction between Enzalutamide and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced sedative effect and consider a different hypnotic that is not CYP3A4 dependent, such as temazepam. Avoid escalating triazolam doses without review.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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