Drug interactions
Enzalutamide + Zolpidem
Severity: Moderate
Enzalutamide and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and can markedly reduce zolpidem concentrations. This may lead to inadequate sleep induction or maintenance.
What this interaction means in plain words
Enzalutamide and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Zolpidem belongs to Central Nervous System.
Why it happens
Enzalutamide induces CYP3A4, increasing the metabolic clearance of zolpidem.
What to do
Assess hypnotic response after starting enzalutamide and adjust the zolpidem dose within the labeled maximum if needed. Consider non-pharmacologic measures or an alternative hypnotic if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Zolpidem?
MediHelp rates the interaction as moderate. Enzalutamide and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and can markedly reduce zolpidem concentrations. This may lead to inadequate sleep induction or maintenance.
How serious is the interaction between Enzalutamide and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess hypnotic response after starting enzalutamide and adjust the zolpidem dose within the labeled maximum if needed. Consider non-pharmacologic measures or an alternative hypnotic if efficacy is lost.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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