Drug interactions
Epcoritamab + Metformin-repaglinide
Severity: Moderate
Epcoritamab and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epcoritamab releases cytokines that can transiently suppress CYP enzyme activity. This may increase repaglinide exposure and the risk of hypoglycemia, particularly around cytokine release syndrome episodes.
What this interaction means in plain words
Epcoritamab and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epcoritamab belongs to Oncology; Metformin-repaglinide belongs to Endocrine.
Why it happens
Cytokine-mediated suppression of CYP3A4 activity reduces repaglinide metabolism.
What to do
Monitor blood glucose during the first weeks of epcoritamab and during CRS. Reduce the repaglinide dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Epcoritamab
- Epcoritamab + Ergotamine Major
- Epcoritamab + Pimozide Major
- Bendamustine + Epcoritamab Moderate
- Carbamazepine + Epcoritamab Moderate
- Clomipramine + Epcoritamab Moderate
- Clozapine + Epcoritamab Moderate
Frequently asked questions
Can I take Epcoritamab with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Epcoritamab and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epcoritamab releases cytokines that can transiently suppress CYP enzyme activity. This may increase repaglinide exposure and the risk of hypoglycemia, particularly around cytokine release syndrome episodes.
How serious is the interaction between Epcoritamab and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during the first weeks of epcoritamab and during CRS. Reduce the repaglinide dose if hypoglycemia develops.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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