Drug interactions
Epcoritamab + Pirfenidone
Severity: Moderate
Epcoritamab and Pirfenidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epcoritamab triggers cytokine release, which can temporarily suppress CYP450 enzyme activity. Pirfenidone is cleared mainly by CYP1A2, so its exposure may rise during cytokine release, increasing the risk of nausea, photosensitivity and liver enzyme elevations.
What this interaction means in plain words
Epcoritamab and Pirfenidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epcoritamab belongs to Oncology; Pirfenidone belongs to Miscellaneous.
Why it happens
Cytokine-mediated downregulation of CYP1A2 reduces pirfenidone metabolism and raises its concentrations.
What to do
Monitor for pirfenidone adverse effects and liver enzymes during epcoritamab step-up dosing and any cytokine release syndrome episode. Reduce or interrupt pirfenidone if tolerability worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Epcoritamab and Pirfenidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Pirfenidone
Other interactions of Epcoritamab
- Epcoritamab + Ergotamine Major
- Epcoritamab + Pimozide Major
- Bendamustine + Epcoritamab Moderate
- Carbamazepine + Epcoritamab Moderate
- Clomipramine + Epcoritamab Moderate
- Clozapine + Epcoritamab Moderate
Frequently asked questions
Can I take Epcoritamab with Pirfenidone?
MediHelp rates the interaction as moderate. Epcoritamab and Pirfenidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epcoritamab triggers cytokine release, which can temporarily suppress CYP450 enzyme activity. Pirfenidone is cleared mainly by CYP1A2, so its exposure may rise during cytokine release, increasing the risk of nausea, photosensitivity and liver enzyme elevations.
How serious is the interaction between Epcoritamab and Pirfenidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pirfenidone adverse effects and liver enzymes during epcoritamab step-up dosing and any cytokine release syndrome episode. Reduce or interrupt pirfenidone if tolerability worsens.
What other medicines interact with Pirfenidone?
MediHelp also lists interactions of Pirfenidone with, for example, Carbamazepine, Ciprofloxacin, Fluvoxamine. The full list is on the Pirfenidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
