Drug interactions
Epcoritamab + Quinine
Severity: Moderate
Epcoritamab and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epcoritamab induces cytokine release that can temporarily suppress CYP enzymes and raise exposure to CYP3A4 substrates like quinine. The effect is greatest around initial dosing and during cytokine release syndrome.
What this interaction means in plain words
Epcoritamab and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epcoritamab belongs to Oncology; Quinine belongs to Anti Parasitic.
Why it happens
Cytokine-mediated downregulation of CYP3A4 activity reduces quinine clearance.
What to do
Monitor for quinine toxicity such as tinnitus and QT prolongation in the first weeks of treatment. Reduce the quinine dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Epcoritamab
- Epcoritamab + Ergotamine Major
- Epcoritamab + Pimozide Major
- Bendamustine + Epcoritamab Moderate
- Carbamazepine + Epcoritamab Moderate
- Clomipramine + Epcoritamab Moderate
- Clozapine + Epcoritamab Moderate
Frequently asked questions
Can I take Epcoritamab with Quinine?
MediHelp rates the interaction as moderate. Epcoritamab and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epcoritamab induces cytokine release that can temporarily suppress CYP enzymes and raise exposure to CYP3A4 substrates like quinine. The effect is greatest around initial dosing and during cytokine release syndrome.
How serious is the interaction between Epcoritamab and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for quinine toxicity such as tinnitus and QT prolongation in the first weeks of treatment. Reduce the quinine dose if toxicity appears.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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