Drug interactions
Epcoritamab + Rasagiline
Severity: Minor
Epcoritamab and Rasagiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epcoritamab induces cytokine release that can transiently suppress CYP enzymes. Rasagiline is mainly metabolized by CYP1A2, so its exposure may increase during cytokine release.
What this interaction means in plain words
Epcoritamab and Rasagiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Epcoritamab belongs to Oncology; Rasagiline belongs to Central Nervous System.
Why it happens
Cytokine-mediated suppression of CYP activity, particularly CYP1A2, reducing rasagiline clearance.
What to do
Monitor for rasagiline adverse effects during the first weeks of epcoritamab and around cytokine release episodes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Epcoritamab
- Epcoritamab + Ergotamine Major
- Epcoritamab + Pimozide Major
- Bendamustine + Epcoritamab Moderate
- Carbamazepine + Epcoritamab Moderate
- Clomipramine + Epcoritamab Moderate
- Clozapine + Epcoritamab Moderate
Frequently asked questions
Can I take Epcoritamab with Rasagiline?
MediHelp rates the interaction as minor. Epcoritamab and Rasagiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Epcoritamab induces cytokine release that can transiently suppress CYP enzymes. Rasagiline is mainly metabolized by CYP1A2, so its exposure may increase during cytokine release.
How serious is the interaction between Epcoritamab and Rasagiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for rasagiline adverse effects during the first weeks of epcoritamab and around cytokine release episodes.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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