Drug interactions
Ephedrine + Ketoprofen
Severity: Minor
Ephedrine and Ketoprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can raise blood pressure and blunt the effect of antihypertensives, and ephedrine is a pressor sympathomimetic, so additive blood pressure elevation is possible. The effect is usually modest and mainly relevant in hypertensive or cardiac patients.
What this interaction means in plain words
Ephedrine and Ketoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ephedrine belongs to Cardiovascular; Ketoprofen belongs to Musculoskeletal.
Why it happens
Additive pressor effects: NSAID sodium and fluid retention with prostaglandin inhibition plus sympathomimetic vasoconstriction.
What to do
Monitor blood pressure when ephedrine is used regularly with ketoprofen in patients with hypertension or cardiovascular disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ephedrine and Ketoprofen, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Ephedrine with Ketoprofen?
MediHelp rates the interaction as minor. Ephedrine and Ketoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs can raise blood pressure and blunt the effect of antihypertensives, and ephedrine is a pressor sympathomimetic, so additive blood pressure elevation is possible. The effect is usually modest and mainly relevant in hypertensive or cardiac patients.
How serious is the interaction between Ephedrine and Ketoprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when ephedrine is used regularly with ketoprofen in patients with hypertension or cardiovascular disease.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
