Drug interactions
Ephedrine + Nebivolol
Severity: Moderate
Ephedrine and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockade can reduce the heart rate and bronchodilator effects of ephedrine. Ephedrine's alpha-mediated pressor effect may remain unopposed, and may cause hypertension with reflex bradycardia.
What this interaction means in plain words
Ephedrine and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ephedrine belongs to Cardiovascular; Nebivolol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism of ephedrine's beta-adrenergic effects by nebivolol.
What to do
Monitor blood pressure and heart rate when ephedrine is used in patients on nebivolol. Titrate ephedrine doses to effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Ephedrine with Nebivolol?
MediHelp rates the interaction as moderate. Ephedrine and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockade can reduce the heart rate and bronchodilator effects of ephedrine. Ephedrine's alpha-mediated pressor effect may remain unopposed, and may cause hypertension with reflex bradycardia.
How serious is the interaction between Ephedrine and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when ephedrine is used in patients on nebivolol. Titrate ephedrine doses to effect.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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