Drug interactions
Ephedrine + Quinidine
Severity: Moderate
Ephedrine and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine has alpha-blocking properties that may weaken the pressor response to ephedrine, so the expected blood pressure rise may be reduced.
What this interaction means in plain words
Ephedrine and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ephedrine belongs to Cardiovascular; Quinidine belongs to Anti Parasitic.
Why it happens
Pharmacodynamic antagonism through quinidine's alpha-adrenergic blocking and vasodilating effects.
What to do
Monitor blood pressure and titrate ephedrine to effect, or consider another vasopressor if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Ephedrine with Quinidine?
MediHelp rates the interaction as moderate. Ephedrine and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine has alpha-blocking properties that may weaken the pressor response to ephedrine, so the expected blood pressure rise may be reduced.
How serious is the interaction between Ephedrine and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and titrate ephedrine to effect, or consider another vasopressor if response is inadequate.
What other medicines interact with Ephedrine?
MediHelp also lists interactions of Ephedrine with, for example, Isocarboxazid, Phenelzine, Procarbazine. The full list is on the Ephedrine page.
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